Solution for injection
Active substance: drotaverine hydrochloride 20 mg/ml
Excipients: nipagin, nipasol, water for injectables
Recreational or racing horses, dogs and cats
Drotaverine is an antispastic compound whose action is based on the significant inhibition of phosphodiesterase enzymatic activity (PDE), responsible with AMP – cyclic (AMPc) to AMP hydrolysis. Phosphodiesterase inhibition results in AMPc concentration increase influencing the decrease of cytoplasmatic concentrations of Ca2+ ions in the muscle fiber. This fact accounts for the effect of drotaverine as Calcium antagonist and contributes to its antispastic effect. The relaxant effect of drotaverine on the smooth muscles does not depend on the type of vegetative innervation. It is likewise efficient on the smooth muscles in the postdiaphragmatic digestive tube, bile tract, urogenital tract and vascular system. Due to its vasodilator effect, it improves blood flow through tissues. Drotaverine crosses the placental barrier.
As antispastic in: spasms of biliary smooth muscles (biliary lithiasis, cholecystitis); spasms of urinary tract smooth muscles (renal, urethral lithiasis, pyelitis, cystitis); as adjuvant in treatment of some digestive conditions (gastric or duodenal ulcer, gastritis, enteritis, colitis, pancreatitis, spastic constipation, meteorism, spasms of cardia and pyloric sphincter), it enhances elimination of trichobezoars in cat; genital disorders (uterine tetanic contractions, severe pains, abortion imminence) in recreational or racing horses, dogs and cats. The spasmolytic activity of the product reduces pain up to full transition.
Severe hepatic, renal or cardiac failure
Hypersensitivity to active substance or any of the excipients.
Do not use in horses intended for human consumption
Arterial hypotension may occur mostly after intravenous administration.
Method of administration
Administer intramuscularly, subcutaneously or slowly intravenously:
- In recreational or racing horses: 160 mg – 200 mg active substance (8 – 10 ml / animal), i.m. or s.c.; repeat if necessary 2 – 3 times / day. In acute abdominal colics, inoculate 8 ml / animal slowly intravenously; repeat if necessary 2 – 3 times / day i.m. or s.c
- In dog: 1 – 2 ml / animal, i.m., s.c. or slowly i.v. 1 – 2 times / day.
- In cat: 0,5 ml – 1 ml / animal, i.m., s.c. or slowly i.v. 1 – 2 times / day.
Administration should be done by the veterinarian or under his/her supervision.
If inoculated intravenously, inject very slowly.
Administer during pregnancy and lactation only after previous assessment of the risk/benefit therapeutic ratio.
Bottles of 20 ml