Solution for injection
Prevention and treatment of selenium and vitamin E deficiencies
Active substances/1000 ml: Sodium selenite 1 g; Vitamin E 15 g; Sodium chloride 9 g;
Excipients (simulsol, potassium sorbate, propylene glycol, distilled water) ad 1000 ml
Selenium is essential for growth process, for increasing fertility in cattle, sheep and goats and for prevention of some deficiencies: skeletal and cardiac myodistrophy, dietetic hepathosis, exudative diathesis in swine and poultry, necrosis and atrophy of pancreas in chickens. Sodium selenite acts in the body via glutathione peroxidase, an enzyme with protective action against oxidative alterations mainly at the cell membrane level. Selenium from parenterally administered sodium selenite enters rapidly into the bloodstream, where binds to plasma proteins, reaching a peak in the tissue after 4-6 hours. Inorganic selenium is converted to organic, biologically active selenium in the liver.
Vitamin E is a fat-soluble vitamin with antioxidant action, which protects the cell against toxic action of peroxides and promotes vitamin A absorption. It is involved in the normal functioning of the genital organs and in the normal evolution of pregnancy.
An increasing of treatment efficiency in deficient animals may occur by associating sodium selenite with vitamin E, due to their synergic action.
Cattle, sheep, goats, swine, domestic cage and aviary birds (hens, turkeys, guinea fowls, quails, pheasants, peacocks, geese, ducks and pigeons).
Romselevit is used both preventively and curatively in myodistrophies and growth disturbances in calves, lambs, kids (especially in early parturitions), piglets, poultry, in piglet’s heptoses, in placental retentions, feeding deficiencies and reproduction disturbances as well as in nonspecific exudative pneumopathies.
Do not use the product in animals with severe hepatic or renal failure.
Selenium poisoning may occur in case of overdose.
METHOD OF ADMINISTRATION
- pregnant cows: 50 ml per animal are injected subcutaneously or intramuscularly in two separate sites, three weeks before parturition, in order to prevent the myodistrophy in the newborn calves.
- pregnant sheep and goats: 5 – 6 ml are injected subcutaneously, two to three weeks before parturition, in order to prevent the myodistrophy in lambs and kids.
- sows: 0.5 – 1 ml per 10 kg of body weight are injected subcutaneously or intramuscularly immediately after establishing the diagnosis of pregnancy in order to promote the foetus growth. The prevention of myodistrophy in piglets is carried out by injecting a dose of 5 ml in pregnant sows, two to three weeks before parturition.
- fowl: 0.05 ml per kg of body weight, intramuscularly.
- In fowl: 0.1 ml per kg of body weight injected intramuscularly
- In calves, lambs, kids and piglets with myodistrophy 2 ml per10 kg of body weight injected subcutaneously.
If necessary, the doses can be repeated after 14 days.
The usual doses are generally well tolerated, but low-protein food or hepatic and renal failures may increase the susceptibility toward Selenium therapeutic dose.
Comply with the recommended doses and assess correctly the animal’s body weights. In case of acute intoxication a symptomatic treatment should be initiated by administration of caffeine and sodium hyposulfite 20%, intravenously, in the usual doses.
Bottles of 20, 50 and 100 ml.